Publikationen 2010

  1. Bachas C, Schuurhuis GJ, Hollink IH, Kwidama ZJ, Goemans BF, Zwaan CM, van den Heuvel-Eibrink MM, de Bont ES, Reinhardt D, Creutzig U, de H, V, Assaraf YG, Kaspers GJ, Cloos J: High frequency type I/II mutational shifts between diagnosis and relapse are associated with outcome in pediatric AML: implications for personalized medicine. Blood 2010;116:2752-2758. http://www.ncbi.nlm.nih.gov/pubmed/20592250
  2. Balgobind BV, Lugthart S, Hollink IH, Arentsen-Peters ST, van Wering ER, de Graaf SS, Reinhardt D, Creutzig U, Kaspers GJ, de Bont ES, Stary J, Trka J, Zimmermann M, Beverloo HB, Pieters R, Delwel R, Zwaan CM, van den Heuvel-Eibrink MM: EVI1 overexpression in distinct subtypes of pediatric acute myeloid leukemia. Leukemia 2010;24:942-949. http://www.ncbi.nlm.nih.gov/pubmed/20357826
  3. Balgobind BV, Zwaan CM, Reinhardt D, Arentsen-Peters TJ, Hollink IH, de H, V, Kaspers GJ, de Bont ES, Baruchel A, Stary J, Meyer C, Marschalek R, Creutzig U, den Boer ML, Pieters R, van den Heuvel-Eibrink MM: High BRE expression in pediatric MLL-rearranged AML is associated with favorable outcome. Leukemia 2010;24:2048-2055. http://www.ncbi.nlm.nih.gov/pubmed/20861917
  4. Balgobind BV, Hollink IH, Reinhardt D, van Wering ER, de Graaf SS, Baruchel A, Stary J, Beverloo HB, de Greef GE, Pieters R, Zwaan CM, van den Heuvel-Eibrink MM: Low frequency of MLL-partial tandem duplications in paediatric acute myeloid leukaemia using MLPA as a novel DNA screenings technique. Eur J Cancer 2010;46:1892-1899. http://www.ncbi.nlm.nih.gov/pubmed/20233657
  5. Creutzig U, Zimmermann M, Dworzak M, Urban C, Henze G, Kremens B, Lakomek M, Bourquin JP, Stary J, Reinhardt D: Favourable outcome of patients with childhood acute promyelocytic leukaemia after treatment with reduced cumulative anthracycline doses. Br J Haematol 2010;149:399-409. http://www.ncbi.nlm.nih.gov/pubmed/20230404
  6. Ehlers S, Herbst C, Zimmermann M, Scharn N, Germeshausen M, von Neuhoff N, Zwaan CM, Reinhardt K, Hollink IH, Klusmann JH, Lehrnbecher T, Roettgers S, Stary J, Dworzak M, Welte K, Creutzig U, Reinhardt D: Granulocyte colony-stimulating factor (G-CSF) treatment of childhood acute myeloid leukemias that overexpress the differentiation-defective G-CSF receptor isoform IV is associated with a higher incidence of relapse. J Clin Oncol 2010;28:2591-2597. http://www.ncbi.nlm.nih.gov/pubmed/20406937
  7. Emmrich S, Putzer BM: Checks and balances: E2F-microRNA crosstalk in cancer control. Cell Cycle 2010;9: 2555-2567. http://www.ncbi.nlm.nih.gov/pubmed/20581444
  8. Gerr H, Zimmermann M, Schrappe M, Dworzak M, Ludwig WD, Bradtke J, Moericke A, Schabath R, Creutzig U, Reinhardt D: Acute leukaemias of ambiguous lineage in children: characterization, prognosis and therapy recommendations. Br J Haematol 2010;149:84-92. http://www.ncbi.nlm.nih.gov/pubmed/20085575
  9. Goemans BF, Zwaan CM, Cloos J, de Lange D, Loonen AH, Reinhardt D, Hahlen K, Gibson BE, Creutzig U, Kaspers GJ: FLT3 and KIT mutated pediatric acute myeloid leukemia (AML) samples are sensitive in vitro to the tyrosine kinase inhibitor SU11657. Leuk Res 2010;34:1302-1307. http://www.ncbi.nlm.nih.gov/pubmed/20435347
  10. Hollink IH, van den Heuvel-Eibrink MM, Zimmermann M, Balgobind BV, Arentsen-Peters ST, Alders M, Willasch A, Kaspers GJ, Trka J, Baruchel A, Creutzig U, Pieters R, Reinhardt D, Zwaan CM: No prognostic impact of the WT1 gene single nucleotide polymorphism rs16754 in pediatric acute myeloid leukemia. J Clin Oncol 2010;28:e523-e526. http://www.ncbi.nlm.nih.gov/pubmed/20644087
  11. Klingebiel T, Creutzig U, Christaras A, Nowak-Gottl U, Gobel U: Milestones of Health Policy and Rare Diseases. Klin Padiatr 2010;222:121-123. http://www.ncbi.nlm.nih.gov/pubmed/20514612
  12. Klusmann JH, Li Z, Bohmer K, Maroz A, Koch ML, Emmrich S, Godinho FJ, Orkin SH, Reinhardt D: miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes Dev 2010;24:478-490. http://www.ncbi.nlm.nih.gov/pubmed/20194440
  13. Klusmann JH, Godinho FJ, Heitmann K, Maroz A, Lee KM, Reinhardt D, Orkin SH, Li Z: Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis. Genes Dev 2010;24:1659-1672. http://www.ncbi.nlm.nih.gov/pubmed/20679399
  14. Niewerth D, Creutzig U, Bierings MB, Kaspers GJ: A review on allogeneic stem cell transplantation for newly diagnosed pediatric acute myeloid leukemia. Blood 2010;116:2205-2214. http://www.ncbi.nlm.nih.gov/pubmed/20538803
  15. Sander A, Zimmermann M, Dworzak M, Fleischhack G, von Neuhoff C, Reinhardt D, Kaspers GJ, Creutzig U: Consequent and intensified relapse therapy improved survival in pediatric AML: results of relapse treatment in 379 patients of three consecutive AML-BFM trials. Leukemia 2010;24:1422-1428. http://www.ncbi.nlm.nih.gov/pubmed/20535146
  16. von Neuhoff C, Reinhardt D, Sander A, Zimmermann M, Bradtke J, Betts DR, Zemanova Z, Stary J, Bourquin JP, Haas OA, Dworzak MN, Creutzig U: Prognostic impact of specific chromosomal aberrations in a large group of pediatric patients with acute myeloid leukemia treated uniformly according to trial AML-BFM 98. J Clin Oncol 2010;28:2682-2689. http://www.ncbi.nlm.nih.gov/pubmed/20439630
  17. Zwaan CM, Reinhardt D, Zimmerman M, Hasle H, Stary J, Stark B, Dworzak M, Creutzig U, Kaspers GJ: Salvage treatment for children with refractory first or second relapse of acute myeloid leukaemia with gemtuzumab ozogamicin: results of a phase II study. Br J Haematol 2010;148:768-776. http://www.ncbi.nlm.nih.gov/pubmed/19995399
  18. Zwaan CM, Reinhardt D, Hitzler J, Vyas P: Acute leukemias in children with Down syndrome. Hematol Oncol Clin North Am 2010;24:19-34. http://www.ncbi.nlm.nih.gov/pubmed/20113894
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